13 Medications You Should Never Mix With Alcohol

By  Courtney Southwick Published on September 13, 2023;  Medically reviewed by  Suzanne Fisher, MS

Here at Billie’s Back Porch, we are not doctors and do not give medical advice. Check with your medical provider before doing anything medical. While you wait for an appointment, put down that glass of wine and read carefully…

The combination of alcohol and certain medications can cause negative interactions, adverse reactions, and even overdose and death. This can happen with prescription medications, over-the-counter (OTC) medications, and even supplements or herbal remedies.

  • One in 10 teenagers and adults take antidepressant or anxiety medications every day, according to the Centers for Disease Control and Prevention (CDC). Anxiety and antidepressant medications that should not be mixed with alcohol include:
    • Zoloft (sertraline)
    • Wellbutrin (bupropion)
    • Symbyax (fluoxetine/olanzapine)
    • Prozac (fluoxetine)
    • Paxil (paroxetine)
    • Pristiq (desvenlafaxine)
    • Abilify (aripiprazole)
    • Cymbalta (duloxetine)
    • Valium (diazepam)
    • Xanax (alprazolam)
    • Eskalith/Lithobid (lithium)
  • Nearly half of the U.S. population has diabetes, prediabetes, or insulin resistance (a precursor to diabetes). Talk to your doctor before drinking alcohol if you take any of the following diabetes medications:
    • Diabinese (chlorpropamide)
    • Glucophage (metformin)
    • Glucotrol (glipizide)
    • Glynase and DiaBeta (glyburide)
    • Micronase (glibenclamide)
    • Orinase (tolbutamide)
    • Tolinase (tolazamide)

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